Month: March 2008

Categories
mexico travel writing

Papers Please…

int-drivers-permit.jpg 

Going to Brazil requires proper foreign stuff like getting a VISA (for me as a Mexican national) and an International Driver’s License based on the 1926 treaty. It’s all prewar and all, a little cardboard booklet in Pre-War Government Grey.

I have papers! Like you see in films when they say ‘Ihre papieren, bitte…’

Some exciting news re sales of “Invisible City” – the Nielsen BookScan data has been crunched and it’s officially the fastest selling UK children’s debut so far this year! Congratulations to Scholastic for their brilliant work selling and promoting the book and many thanks to everyone who’s read it, blogged about it and given it a terrific review on Amazon or elsewhere. Guys…it’s working!


see Pedro Almodovar Blog

Meanwhile I have found a way to fangirl one of my favourite movie directors, that Castilian genius, Pedro Almodovar. He has a blog where he’s blogging about making his forthcoming movie, “Broken Embraces”.

I almost swooned with pleasure to read that he’s been writing in the ‘Las Mananitas’ hotel in Cuernavaca and to see from his photos that he’s been to Tepoztlan. Both are small towns outside Mexico City, around a hour’s drive away through tree-covered mountains, and both places where we’ve spent wonderful times with friends and family.

I was also delighted to read about his recollections of “Night of the Iguana”, a film I also admire. Of the monologue at the end where Deborah Kerr’s character movingly and naturally speaks of the one moment of (questionable) intimacy in her entire life, Almodovar writes:

“When a character has captured our attention and decides to tell us something intimate, something he has never confessed to anyone, there’s nothing better than letting the actor act. There are no digital effects, no frantic editing that can compare to the intensity of an actor’s face.”

I always try to achieve that cinematic moment in what I write. Robert McKee said that if there’s one message he’d telegraph to movie producers it’s this: MEANING produces EMOTION.

As in; not explosions, special effects, car chases etc; but that moment where you see on the actor’s face the sudden tumbling of the lock’s mechanism, the realisation, admission, confession.

Now in my case I’d like the car chases and the visual thrill too, thanks very much, but when the moment of meaning arrives, what I’m thinking about is the look on an actor’s face.

So – another blog to follow. Yay!

Categories
nostalgia science

Bioscience Nostalgia

Every so often I get all nostalgic for molecular biology. Ah, they were good days, so much work to do that you hardly had time to think about anything but science.

I found some videos on YouTube which made me smile. This has got nothing to do with Joshua Files, btw, but if you’ve half an interest in science geek humour, and the nostalgic musings of a former scientist then read on…


Here’s the PCR song. It’s from BIO-RAD, the manufacturer of the thermal recycling machine which makes the Polymerase Chain Reaction possible (at least optimal). Lucky BioRad, they had a bright employee named Kary Mullis who when faced with the dilemma that piqued many scientists in the 1980s, didn’t stop thinking. No; he took a long drive up to Marin County (or from…) and thought long and hard about it.

This was the dilemma: We were all using purified enzymes like DNA polymerase to amplify DNA ‘in vitro’ (as in, not in a cell but in a test-tube), but only on a small scale. We weren’t making enough DNA to use in DNA subcloning work or enough to see on a gel with the naked eye. It wasn’t possible.

We all knew that DNA can be replicated simply by melting the two strands, using DNA polymerase to fill in each strand. In theory, if you kept repeating the process 1 molecule would become 2, then 4, 8,16,32,64 etc. But the process of melting the DNA each time would destroy the enzyme. And it was a big hassle to keep swapping the DNA from water baths to ice baths to cycle the process of melting/annealing.

And that’s where most of us stopped thinking.

Kay Mullis, however, remembered that some bacteria exist at high temperatures (e.g. near volcanic vents under the sea), and have heat-stable enzymes. If he could use the DNA polymerase from such a bacteria, it should be possible to invent a machine that would heat-and-cool tubes for the optimum times so that small amounts of DNA could be melted and annealed 20,30,40 times.

And that would seriously amplify the molecules. That would make it possible to eventually detect teeny weeny amounts of DNA.

And so PCR was invented. As an employee Mullis didn’t get rich but he did invent a process that made the lives of all molecular biologists much easier, revolutionised forensic science and paternity suits.

For some reason I only once had a chance to use PCR. In my early days it wasn’t around and later it just wasn’t applicable to what I was researching, until the last month or so. And then I used it to detect a subcloned DNA molecule I’d made the day before. It was the fastest subcloning I ever did and the PCR worked first time, like a dream…and I thought Jeeeez…why wasn’t this around 6 years ago?!

Categories
mexico nostalgia zero moment

Looking for inspiration: Remedios Varo

Some writers like to have a vague idea where they’re going when they write and make it up as they go along, some writers like to spend a great deal of time with the plotting and planning.

I’m one of the planners. I’ve tried it the other way – with me it tends to produce plot structures that lack sufficient impact at the key points. So now, I plan.

But a story also has needs to have some magical, organic quality; something that feels as though it crept in by itself, wasn’t calculated into the mix from the start. Even if actually, it was…

Every writer has their own way of factoring in that magical bit. I suspect we all discover it on our own. Mind-altering substances might do the trick, but that’s a bit risky…

My own ‘method’ came from the realisation that even working to a structured plot, there was still room for movement. So even my ‘finished’ plot plans are in fact only about 85% of the way there.

The last 15% has to be found during the writing. And with me, it is always inspired from outside.

It seems to be something about understanding what makes you tick and connecting something in the story with that.

Without getting too psychoanalytical, we all have something deep down that we really care about and drives us.  Some people are very self-aware; they know what this is…the kind of people who care deeply about politics or religion…are probably going to write books that reflect their thoughts on that.

But if lie me you’re generally vague and mixed-up, it’s a bit more complicated!

However, by accident, I did find the way to extract this magic final 15%. And so far it has worked every time.

I’m not telling though! Nope; that’s going to be my secret.

Here’s a clue though, one thing that inspired me today, in finding the some of the magic 15% for Joshua book 3.

It’s a picture by Remedios Varo, a Mexican artist, a surrealist painter of fantastical works. A close friend of mine in Mexico City introduced me to her work when we were teenagers. I remember a very happy afternoon we spent together in the Museum of Modern Art in Chapultepec looking at these paintings…

The painting above is called Naturaleza Muerta Resucitado which translates as ‘Natural Death Resuscitated’.

Categories
mexico

With the Bohemians – A huevo!


Alonso, Mario, Hector and Pablo of the OU Mexican Society

After Mass last week I overheard two people talking in the shop near church. Their accents gave them away as Mexicans, so I introduced myself as a fellow Mexican. Oxford has a few Mexican graduate students nowadays and over the years I’ve got to know a few of them, which has been a wonderful way to meet Mexican people who are a) much younger than me and b) not related to me!

Pablo invited me to listen to him and some friends playing ‘trova’ at a ‘Bohemian Night’ at Exeter College MCR. ‘Trova’ are soft, latin-american modern folk songs, often with political sentiments. So I sneaked out of the house last Saturday and joined the Young People in the MCR.

Listening to them play, I was transported back to my childhood when my  uncle Jose Luis (‘Pepe’) and some student mates (my mother called them ‘the boys’) of his came to Europe travelling, back in the 1970s. Like Pablo and his pals, they also brought guitars and songs from old Mexico. I was a very impressionable young girl at that time and decided that an intrinsic part of being attractive as a latino male was undoubtedly the ability to sing and play guitar.

I was glad to see that these guys lived up to that stereotype. Like Pepe and ‘the boys’ back in the day, these guys had an impressive command of old Mexican songs by Agustin Lara and Jose Alfredo Jimenez, rancheras, trova songs, ballads…and that was before they began riffing with the audience in English, covering the Beatles, Bob Dylan, Eric Clapton, The Eagles,  Don Mclean and Radiohead.

(A highlight was when they played “Twist and Shout” by the Beatles and then without changing the guitar riffs at all – because it’s exactly the same tune – went straight into the older Mexican jarocho song ‘La Bamba’.)

Very bohemian! And quite satisfyingly Mexican, too. Viva Mexico!

I might be going to talk to the Oxford University Mexican Society about ‘The Joshua Files’. Yes, I did tell them, many times, that it’s a children’s book…

 (NB ‘a huevo’ is Mexican slang for saying ‘too right’. And like most Mexican slang, it is probably rather crude…)

Categories
raves

The World According to LD

I am so enjoying the new series of ‘Curb Your Enthusiasm’ on More4.

The premise for the series is as gloriously ridiculous as ever, some of the story concepts so featherweight as to be wholly insubstantial and yet still I laugh louder than at any other current comedy show (and it’s not like I’m not trying, I have started watching three other new comedy series this year).

Here’s Larry David (LD) doing his trademark ‘hard stare’. It puts me in mind of Paddington bear, who also had a famous hard stare.

It takes huge skill to make comedy out of ‘nothing’, but Seinfeld and 5 series of Curb don’t seem yet to have exhausted this guy. Mind you that’s not what some people are saying…some think that this 6th series shows signs of tiring. Well maybe series 6 hasn’t yet come up with anything as roll-on-the-floor-laughingly funny as ‘The Doll’ or ‘The Grand Opening’, but when the notion of comedy based on nothing-or-not-much has taken hold in lots of new comedy shows, CYE proves that Larry David is still…The Master.

All hail. Larry, you are untouchable! We’re not worthy, etc, etc.